Myoepithelial carcinoma malignant myoepithelioma of the parotid. Epithelial myoepithelial carcinoma of head and neck region. Sep 10, 2018 learn indepth information on epithelial myoepithelial carcinoma of salivary gland, its causes, symptoms, diagnosis, complications, treatment, prevention, and prognosis. Epithelial myoepithelial carcinoma emc is a lowgrade, malignant biphasic salivary tumor of probable intercalated duct origin that comprises 1% to 2% of all salivary neoplasms. Epithelialmyoepithelial carcinoma of high grade transformation. Epithelialmyoepithelial carcinoma of salivary gland. Clear cell predominance within myoepithelial carcinoma is rare but well described. Combined myoepithelial carcinoma and myoepithelioma in soft. Approximately 66% of these tumors occur in a part of the salivary gland, known as the parotid gland. Epithelialmyoepithelial carcinoma of salivary glands. Myoepithelial tumours are a heterogenous group of tumours which demonstrate myoepithelial differentiation.
A myoepithelial carcinoma, a rare malignant salivary gland neoplasm, arose in a. Myoepithelial carcinoma mc is a rare, locally aggressive malignant neoplasm of the salivary glands. Mar 18, 2015 myoepithelioma was recognized as a histologically distinct entity by the world health organization who in 1991. Prognostic factors in myoepithelial carcinoma of salivary glands. Myoepithelial carcinoma and epithelialmyoepithelial carcinoma. Epithelialmyoepithelial carcinoma is an uncommon neoplasm comprising 1% of all salivary gland tumours. Sep 24, 2014 soft tissue myoepithelial carcinoma and myoepithelioma are rare entities, part of myoepithelial tumors. Although its contribution to benign and some malignant pathologies is recognised, it has been largely neglected in molecular and biological studies.
The clear cell variant of myoepithelial carcinoma is extremely rare and only about 51 cases of. Primary cutaneous neoplasms of myoepithelial differentiation are uncommon. Primary myoepithelial carcinoma of palate world journal of. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 toll free. In view of the paucity of management guidelines and the possible. Jul 28, 2005 adenomyoepithelial tumours and myoepithelial carcinomas of the breast are primarily defined by the presence of neoplastic cells with a myoepithelial immunophenotype. It is similar to salivary gland myoepithelial tumors showing same histological features morphology. Presence of myoepithelial cells in a hyperplastic tissue proves the benignity of the gland and, when absent, indicates cancer.
Epithelial myoepithelial carcinoma emc is a tumour consisting of various proportions of two cell types which typically form ductlike structures. Myoepithelial differentiation in breast carcinoma article pdf available in tumori 941. We report a case of cutaneous myoepithelial carcinoma in a 47yearold man with a history of endstage renal disease and renal transplant 19 years prior who presented to the hospital with a 3month history of diffuse bone pain and an ulcerated scalp mass with multiple. Myoepithelial neoplasms in skin and soft tissue are classified as mixed tumorchondroid syringoma, myoepithelioma, and myoepithelial carcinoma. Report of a unique case of myoepithelial carcinoma of left. To the best of our knowledge, such an association has never been reported in the literature. Herein we report the morphological features of myoepithelial carcinoma in a 74yearold female clinically presenting with a parotid mass.
It has been proposed that the presence of myoepithelial cells overlying epithelial malignant cell clusters suggests dcis. Epithelial myoepithelial carcinoma of the parotid gland author. Epithelial myoepithelial carcinoma of parotid a rare case report. Epithelialmyoepithelial carcinoma emc is regarded as a rare lowgrade malignant tumor of the. Learn indepth information on epithelial myoepithelial carcinoma of salivary gland, its causes, symptoms, diagnosis, complications, treatment, prevention, and prognosis. May have high grade transformation dedifferentiation. We herein present a unique case of mc of left parotid gland which metastasized to bilateral cavernous sinuses. Wed like to understand how you use our websites in order to improve them. Epithelialmyoepithelial carcinoma emc is a lowgrade, malignant biphasic salivary tumor of intercalated duct origin that comprises 12% of all salivary neoplasms. Only a limited number of case reports have been descibed to date. There is a need for the establishment of standard criteria to aid in its identification and correct categorization. An inner layer of duct lining cells and an outer layer of clear cells, which typically form doublelayered ductlike structures. These tumours are typically found in structures containing glandular or ductal tissues, but are increasingly reported in bone, soft tissue and cutaneous tissues. Pathology outlines epithelial myoepithelial carcinoma.
Current classification schemes are based on purely descriptive features and an assessment of individual prognosis is still problematic. Epithelial myoepithelial carcinoma is a rare tumor which makes up about 0. Article information, pdf download for hepatic myoepithelial carcinoma in a. The treatment carried out was wide surgical resection. The tumor shows wide morphologic and cytologic diversity in a similar way to its benign counterpart, myoepithelioma, with evidence of malignant change. Myoepithelial carcinoma an overview sciencedirect topics. Clear cell carcinoma consists exclusively of luminaltype epithelial cells, whereas myoepithelial carcinoma shows only cells that demonstrate myoepithelial differentiation. Sep 27, 2015 myoepithelial carcinoma malignant myoepithelioma is a rare salivary gland tumor composed entirely of myoepithelial cells that exhibit a dual epithelial and smooth muscle phenotype. Jan 20, 2012 the objective of the study is to document the clinical, histopathological and immunological findings of epithelial myoepithelial carcinoma emec which is an uncommon neoplasm.
Malignant myoepithelioma of the breast is an extremely rare tumor composed entirely or almost entirely of malignant spindle cells with myoepithelial differentiation. Adenomyoepithelial tumours and myoepithelial carcinomas of. Myoepithelial carcinoma meca is an underrecognized rare tumor with a. Mixed tumorschondroid syringoma show tubuloductal differentiation, appearing similar to their salivary gland counterparts fig. Soft tissue myoepithelial carcinoma malignant myoepithelioma is a rare, malignant subtype of myoepithelial tumour, with a. A series of 27 adenomyoepithelial tumours of the breast was analysed immunohistochemically. Myoepithelial and epithelialmyoepithelial carcinoma are two tumour entities that consist largely of malignant myoepithelial cells. Myoepithelial carcinoma is an uncommon, malignant, soft tissue tumor of myoepithelial cells. Unusual biliary myoepithelial carcinoma in livercase report and. Patients a total of 51 patients with myoepithelial rich. Donath and coworkers are usually accredited with calling attention to this tumor in 1972.
Myoepithelial carcinomas exhibit a wide spectrum of cytomorphologic features and diverse clinical outcomes. Hunt, in diagnostic immunohistochemistry third edition, 2011. We report a 61yearold patient with breast myoepithelial carcinoma who developed locoregional and distant metastases and received many chemotherapy. Dec 01, 2005 salivary duct carcinoma of the larynx. It is also known as a malignant myoepithelial tumor. Also islands, nests or sheets of spindle cells, plasmacytoid hyaline cells. Epithelial myoepithelial carcinoma emca is a salivary tumor with dual cell population. However, the recognition of myoepithelial cells in aspirates may be difficult.
Please remove adblock adverts are the main source of revenue for dovemed. Derived from epithelial cells and destined to become a part of the muscular system. Nov 18, 2016 if you have problems viewing pdf files, download the latest version of adobe reader. Article pdf available in clinical and translational oncology 1711 july 2015 with 354 reads how we measure reads a read. Despite several commonalities between these entities, various features distinguish. Here we present the cytologic findings from a case of infiltrating myoepithelial carcinoma of the breast in a 52yearold female and. Myoepitheliomas are tumors arising from myoepithelial cells mainly or exclusively. The few cases that have surfaced firmly document the histopathology of this tumor, but its cytologic characteristics seemingly have been described in only one other report. In this case report, we describe, to our best of knowledge, the first case of a patient with a synchronous bilateral epithelialmyoepithelial carcinoma of the parotid gland. Cutaneous myoepithelial carcinoma with disseminated. Myoepithelial carcinoma of the parotid gland article pdf available in the malaysian journal of pathology 361.
The mammary myoepithelial cell cinderella or ugly sister. Myoepitheliomas mostly occur in salivary glands, as well as in breast, skin, and lung. Myoepithelial carcinoma of the breast pubmed central pmc. Myoepithelial definition of myoepithelial by the free. For language access assistance, contact the ncats public information officer. Clear cell myoepithelial carcinoma of the upper lip a rare. The patient was followed up for 2 years and was symptom free. Myoepithelial cells in these cases constitute the basal cell layer of an epithelium that harbors the epithelial progenitor. Epithelial myoepithelial carcinoma emc is a rare tumor of salivary gland which presented in a 65 year old female as a swelling behind the right ear. It is a benign salivary gland tumor that consists entirely of myoepithelial cells with variable cellular morphologies including spindle, epithelioid, plasmacytoid, or clear cells. Pdf epithelialmyoepithelial carcinoma of the hard palate. Dedifferentiation is defined as highgrade malignant tumor development out of a lowgrade malignant tumor. Only few evidences on its metastatic behavior are available in the literature.
Objective to analyze the importance of unique cytoarchitectural patterns and the immunohistochemical profile in the diagnosis of myoepithelial carcinomas. One of the limitations of fine needle aspiration biopsy fnab of the breast is in distinguishing invasive carcinoma idc from ductal carcinoma in situ dcis. Myoepithelial carcinoma of the breast is rare and difficult to diagnose owing to its varied morphological characteristics. Donath and coworkers 233 are usually credited with calling attention to this tumor in 1972. Pdf myoepithelial differentiation in breast carcinoma.
It was included first in the second who classification of 1991 and defined as a rare malignant epithelial. Fine needle aspiration cytology fnac of the swelling was suggestive of pleomorphic adenoma. They are predominantly found in the parotid gland 1 and represent approximately 1% of salivary gland tumours. They were incorporated into the world health organization classification of soft tissue tumors in 2002. We present an adenocarcinoma tumor of the parotid gland that was dedifferentiated from a lowgrade epithelial myoepithelial carcinoma and was followed up for 3 years.
Infiltrating spindle cells with fibrillar eosinophilic cytoplasm tumor appears to arise from myoepithelial cells of ductules at periphery of lesion. The reason for this has been the perception that its role in normal physiology is confined to lactation and the belief that most breast cancers arise from luminal epithelial cells. Complete excision is the preferred treatment method for myoepithelioma. Synchronous bilateral epithelialmyoepithelial carcinoma of. Nov 18, 2016 myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. Our patient, a 46yearold female, presented with a left parotid mass of 20year duration. The most common malignant major and minor salivary gland tumor is the mucoepidermoid carcinoma, which comprises about 10% of all salivary gland neoplasms and approximately 35% of malignant salivary gland neoplasms. Epithelialmyoepithelial carcinoma with highgrade transformation of. It is generally composed of variable proportions of two cell types. Epithelialmyoepithelial carcinoma of parotid a rare case. Focally, there are ducts or tubules with an outer rim of myoepithelial cells and inner, dark ductal cells with scant eosinophilic cytoplasm and round, bland nuclei.
There is an inner layer of ductlining cells and an outer layer of clear myoepithelial cells 52. Case study of a parotid gland adenocarcinoma dedifferentiated. Here we present an exceptional case of myoepithelial carcinoma and myoepithelioma association. Myoepithelial carcinoma malignant myoepithelioma of the breast is a rare tumor, for which only a limited number of reports have been published. Fnab revealed hypercellular, threedimensional clusters. Polymorphous lowgrade adenocarcinoma at the base of the tongue. For myoepithelial carcinoma, complete excision with tumor free margin remains the first choice of treatment,6,17,18,22 in spite of the possibilities of local recurrence and distant metastasis to lung, kidney and brain. Epithelial myoepithelial carcinoma emca is a rare malignant tumour that typically arises in a salivary gland and consists of both an epithelial and myoepithelial component. We describe an unusual salivary neoplasm, an epithelial myoepithelial carcinoma emec of the parotid gland, that occurred in a 64yearold man. Infiltrating myoepithelial carcinoma remains a rarely encountered lesion of the breast. Most of the reports emphasized diagnosis and pathology but not biological behavior and treatment. Myoepithelial carcinoma malignant myoepithelioma mc consists almost entirely of myoepithelial cells with only the occasional ductlike structure.
Its clinical, radiological and histopathological characteristics are described herein. Infiltrating myoepithelial carcinoma of the breast, a case. Myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. Epithelialmyoepithelial carcinoma emc was first described by danath et al. Epithelial myoepithelial carcinoma emc is a rare biphasic tumor of the salivary gland. Pedunculated cribriform adenocarcinoma of the base of the tongue. Mr images showed a lesion with intermediate t1weighted signal intensity and a relatively high t2weighted signal intensity. As a result of their morphologic heterogeneity, they can be confused easily with many tumours. Carcinoma ex pleomorphic adenoma, an uncommon neoplasm of the parotid gland, accounts. Invasive myoepithelial carcinoma ex pleomorphic adenoma of the. A ct scan showed a fairly well defined heterogeneous lesion with smooth margins and slight enhancement. Get a printable copy pdf file of the complete article 2.
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